Arimidex 101

Arimidex (Anastrozole) is what is classified as an aromatase inhibitor. Its original designed use was to treat breast cancer in women by lowering estrogen. It was eventually discovered that Arimidex could benefit bodybuilders by blocking estrogen formation or lowering already existing levels.

As I talked about in the Nolvadex 101 article, the biggest difference between an aromatase inhibitor such as Arimidex and a selective estrogen receptor modulator like Nolvadex is that Arimidex blunts estrogen formation and Nolvadex simply control it by not allowing any receptor binding.

However, this doesn’t mean that already circulating levels of estrogen are not present just because Nolvadex is included in the drug regimen.

See also: How to Keep Estrogen Under Control

Arimidex works by reducing the aromatase enzyme which is what is the cause of elevated estrogen levels and a byproduct of drugs that can aromatize while on cycle.

Arimidex is superior to Nolvadex in almost every possible way with the exception of stimulating luteinizing hormone during cycle recovery (studies are showing that nolvadex is better at this than AI’s, but this is a double edged sword because AI’s are better at combating estrogen rebound)

If I had my choice on a SERM or an AI for post cycle recovery I would opt for an AI coupled with HCG and Clomid.

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19 thoughts on “Arimidex 101”

  1. This is a great estrogen blocker, but can mess with cholesterol levels. Not saying don’t use but talking to my doc and looking at my blood work I can see differences in cholesterol.

    • yes, it can do that, thats why you only want to use it at just enough to combat estrogen and cycle off (or for the guys on TRT drop to a NORMAL TRT dose for periods of time, where not as much AI is needed)

  2. I’m on TRT 1cc a week of testosterone cypionate’s which is 200 mg a week , my estrogen got pretty high so he prescribed me Arimadex A half a pill every day but I got nervous with cholesterol so now I cut the pill
    Into four pieces and take a quarter of a pill every other day. I’m waiting to see how my next blood test locks . Do you think I’d be better off taking Nolvadex? Thank you and God bless .

    • no, arimadex is superior to nolvadex because it prevents estro formation where nolva just keeps it from binding to receptors but doesnt stop formation. 1/2 a pill everyday sounds like too much if the pills are 1mg, but script-wise they’ll occasionally dose them lower so I really don’t have an answer for this without knowing. Usuaully 1/2mg twice weekly is normal for using 200mg/wk of test

  3. What about if you’re just using arimidex and clomid as an alternative to TRT. How much arimidex and clomid, and how often? I was told 50mg clomid every day and 0.25 mg arimidex every 3 days. Is that a good protocol?

  4. I’m a beginner. I went ahead and started the pymirid cycle for beginning cycles.

    I’m on my second week of test cyph mondays I do my shot the first week felt fine 2nd week i feel a little weird but i believe I’m getting sick cause i went swimming and due to weather changing
    I just now got armidex. Its 1mg but I dont know if that’s too much lit of info says take .5 mg there capsules not pill form can you help me out please.

    • This is common onset of test, it’s called the test flu and it’ll pass. Go .5 on adex 3x a week , u shouldnt need more than that because u don’t wanna crash estrogen , u need a little of it to feel normal

  5. Hey John,

    Running a cycle of Test P 100mg every other day for 16 week cycle. Would you recommend 20 mg of Nolvadex every other day? or .5 Arimidex every other day? Have both. Or would you run the Arimidex post cycle?

    • It’s propionate so it probably ain’t going to aromatize much at all. Everyone is do different when it comes to dialing in estrogen, .5 adex every other day may even be too much, start with .5mg adex twice weekly

  6. Hey John, how long after discontinuing nolvadex do I need to wait before I can safely start arimidex? Running 350mg of test cyp a week. Ran nolvadex for 2 weeks to keep estrogen symptoms (moodiness, depression, lethargy) down while waiting for adex to come in. Now I have adex, can I start it the next day and discontinue nolvadex? Or do I need to wait foe nolvadex to clear my system?

  7. Hey John .

    TRT question for you , currently taking 200mg test cyp wk . Clomid 25 mg 3 x week and Arimidex 2mg per week. Definitely think the Arimidex is too high of a dose having some side effects . What do you think I need to drop the Arimidex too ?

    Thanks !


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